Gene information
Official symbol PF4
Official full name platelet factor 4
Gene type protein-coding gene
Chromosome4q13.3
Alias symbolSCYB4; CXCL4
Resources
Entrez Gene 5196
HGNC HGNC:8861
Ensembl ENSG00000163737
Vega OTTHUMG00000130009
UCSC uc003hhi.4
GO terms: 92 records
GO Description Category LogP Number of genes Detail
GO:0001562 response to protozoan GO Biological Processes -4.01585848 7 More
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002761 regulation of myeloid leukocyte differentiation GO Biological Processes -12.4818724 17 More
GO:0002763 positive regulation of myeloid leukocyte differentiation GO Biological Processes -8.56410954 10 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO Biological Processes -9.16710904 33 More
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO Biological Processes -6.95524830 22 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008009 chemokine activity GO Molecular Functions -11.8970416 12 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0010744 positive regulation of macrophage derived foam cell differentiation GO Biological Processes -12.0744578 9 More
GO:0016525 negative regulation of angiogenesis GO Biological Processes -31.9326641 51 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019730 antimicrobial humoral response GO Biological Processes -11.7829906 16 More
GO:0030168 platelet activation GO Biological Processes -17.9354931 20 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030593 neutrophil chemotaxis GO Biological Processes -16.9449855 18 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031091 platelet alpha granule GO Cellular Components -43.3287145 36 More
GO:0031093 platelet alpha granule lumen GO Cellular Components -40.0105787 31 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032760 positive regulation of tumor necrosis factor production GO Biological Processes -21.1788990 23 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042379 chemokine receptor binding GO Molecular Functions -11.1027858 13 More
GO:0042832 defense response to protozoan GO Biological Processes -4.13020121 7 More
GO:0044403 biological process involved in symbiotic interaction GO Biological Processes -18.5885778 29 More
GO:0045236 CXCR chemokine receptor binding GO Molecular Functions -7.10577702 6 More
GO:0045346 regulation of MHC class II biosynthetic process GO Biological Processes -9.43730348 7 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045637 regulation of myeloid cell differentiation GO Biological Processes -9.39364926 18 More
GO:0045638 negative regulation of myeloid cell differentiation GO Biological Processes -3.67865682 7 More
GO:0045639 positive regulation of myeloid cell differentiation GO Biological Processes -7.07849207 11 More
GO:0045649 regulation of macrophage differentiation GO Biological Processes -4.88843929 5 More
GO:0045651 positive regulation of macrophage differentiation GO Biological Processes -4.33413085 4 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0051702 biological process involved in interaction with symbiont GO Biological Processes -12.570571 16 More
GO:0051873 killing by host of symbiont cells GO Biological Processes -7.35623750 7 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide GO Biological Processes -7.52692728 10 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070098 chemokine-mediated signaling pathway GO Biological Processes -11.4747808 14 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071621 granulocyte chemotaxis GO Biological Processes -16.4324548 18 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0097530 granulocyte migration GO Biological Processes -19.1764933 21 More
GO:1901099 negative regulation of signal transduction in absence of ligand GO Biological Processes -4.18352224 5 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901343 negative regulation of vasculature development GO Biological Processes -32.5354692 52 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1902105 regulation of leukocyte differentiation GO Biological Processes -18.8286876 32 More
GO:1902107 positive regulation of leukocyte differentiation GO Biological Processes -14.6775052 22 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -20.7768498 23 More
GO:1903706 regulation of hemopoiesis GO Biological Processes -16.2759166 33 More
GO:1903708 positive regulation of hemopoiesis GO Biological Processes -14.6775052 22 More
GO:1990266 neutrophil migration GO Biological Processes -18.6358512 20 More
GO:1990868 response to chemokine GO Biological Processes -10.9019396 14 More
GO:1990869 cellular response to chemokine GO Biological Processes -10.9019396 14 More
GO:2000181 negative regulation of blood vessel morphogenesis GO Biological Processes -32.6997315 52 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
GO:2001236 regulation of extrinsic apoptotic signaling pathway GO Biological Processes -20.7647111 26 More
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO Biological Processes -19.1764933 21 More
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand GO Biological Processes -4.65044629 6 More
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO Biological Processes -4.18352224 5 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
hsa04062 Chemokine signaling pathway KEGG Pathway -9.12263704 17 More
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
platelet factor 4 proteomics depression[prognosis (bad)] old myocardial infarction Kuijpers PM et al. Psychiatry Res. 2002
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